Network Pharmacology Analysis and Surface Plasmon Resonance Validation of Active Compounds and Molecular Targets in Siwei Jianbu Decoction for Blood Stasis in Diabetic Patient

The network pharmacology and virtual screening analysis has been performed to identify 20 potential drug targets and 59 active compounds regarding Siwei Jianbu Decoction for Blood Stasis in Diabetic Patient. Binding free energy analysis based on the molecular docking and MD simulations identified the EGF protein and the quercetin possessed good binding affinity. SPR assay validated the quercetin could bind the EGF protein with an affinity constant at 25.5 μM.