香豆素
恶性疟原虫
IC50型
体外
细胞毒性
化学
细胞毒性T细胞
分馏
传统医学
药理学
生物化学
生物
色谱法
疟疾
免疫学
医学
有机化学
作者
Hyung‐In Moon,Jai‐Heon Lee,Young Choon Lee,Kyoung-Sook Kim
标识
DOI:10.3109/08923973.2011.559248
摘要
The butanol-soluble fraction of the dried root of Angelica gigas exhibited significant protection against chloroquine-sensitive strains of Plasmodium falciparum using the parasite lactate dehydrogenase assay method. Using antiplasmodial activity-guided fractionation, five coumarins, marmesinin (1), nodakenin (2), skimmin (3), apiosylskimmin (4), and magnolioside (5), were isolated and evaluated for in vitro antiplasmodial activity, as well as for their cytotoxic potential on SK-OV-3 cancer cell lines. Compounds 1 and 5 showed notable growth inhibitory activity against chloroquine-sensitive strains of P. falciparum with IC50 values of 5.3 and 8.2 μM. The compounds showed no significant cytotoxicity (IC50 > 100 μM) toward the SK-OV-3 cancer cell line. This is the first report on the antiplasmodial activity of these coumarin derivatives from the dried root of A. gigas.
科研通智能强力驱动
Strongly Powered by AbleSci AI