PTEN公司
前列腺癌
前列腺切除术
前列腺
组织微阵列
生化复发
Erg公司
免疫组织化学
阶段(地层学)
医学
免疫染色
病态的
癌症
腺癌
桑格测序
病理
内科学
肿瘤科
生物
突变
基因
细胞凋亡
PI3K/AKT/mTOR通路
遗传学
古生物学
眼科
视网膜
作者
Armelle Vinceneux,F. Bruyère,O. Haillot,T. Charles,Alexandre de la Taille,Laurent Salomon,Yves Allory,I. Ouzaïd,Laurence Choudat,Morgan Rouprêt,Éva Compérat,Nadine Houédé,Jean-Baptiste Beauval,Patrick Vourc’h,Gaëlle Fromont
出处
期刊:The Prostate
[Wiley]
日期:2017-07-12
卷期号:77 (12): 1242-1250
被引量:25
摘要
Background Ductal adenocarcinoma (DAC) is a rare and aggressive subtype of prostate cancer (PCa). In the present study, we analyzed the clinical and biological characteristics of DAC, in comparison with high grade conventional acinar PCa. Methods Samples and data were retrospectively collected from seven institutions and centrally reviewed. Immunohistochemistry was performed on tissue microarrays to assess the expression of candidate proteins, based on the molecular classification of PCa, including ERG, PTEN, and SPINK1. SPOP mutations were investigated from tumor DNA by Sanger sequencing. Relationships with outcome were analyzed using log‐rank analysis and multivariable Cox regression. Results Among 56 reviewed prostatectomy specimens, 45 cases of DAC were finally confirmed. The pathological stage was pT3 in more than 66% of cases. ERG was expressed in 42% of DAC, SPINK1 in 9% (all ERG‐negative), and two cases (ERG‐negative) harbored a SPOP mutation. Compared to high grade conventional PCa matched for the pathological stage, cell proliferation was higher ( P = 0.04) in DAC, and complete PTEN loss more frequent ( P = 0.023). In multivariate analysis, SPINK1 overexpression ( P = 0.017) and loss of PSA immunostaining ( P = 0.02) were significantly associated with biochemical recurrence. Conclusion these results suggest that, despite biological differences that highlighted DAC aggressiveness, the molecular classification recently proposed in conventional PCa could also be applied in DAC.
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