Drug-induced liver injury (DILI) is the liver injury caused by drugs or their metabolites, which is the common cause of live failure. Currently, there is still a lack of effective predictors and diagnostic and therapeutic methods for DILI. To gives an introduction to DILI from the aspects of risk factors, diagnostic criteria, causality assessment, etc. To understand the latest research progress in DILI can make for timely identification of patients susceptible to DILI; proper use of causality assessment can help standardize the diagnosis and treatment of DILI.