Pharmacokinetics of N,N-diacetylcystine in Beagle dogs

Purpose To study the iv pharmacokinetics of N,N-diacetylcystine(DiNAC)in Beagle dogs.Methods12 Beagle dogs were divided into 3 groups.A single dose of 25,12.5 and 6.25 mg/kg of DiNAC was given by iv.Serial blood samples were collected at the designed time points.The plasma DiNAC concentration was measured by RP-HPLC.Pharmacokinetic parameters were computerized by DAS program.ResultsAfter intravenous injection of single dose DiNAC,the plasma concentration versus time curves of DiNAC conformed to two-compartment model.The AUC0→∞ and Cmax were lined with the iv dose(r=0.999 3 and 0.993,respectively);t1/2α was 1.1-1.9 min,t1/2β was 34.2-47.3 min and Vd was 0.38-0.49 L/kg,which had no significant deviation between groups(P0.05).ConclusionThe pharmacokinetics of DiNAC conformed to two-compartment model in Beagle dogs after single dose iv.Distribution and elimination of DiNAC were rapid.