Identifying Mechano-Modulators of Myometrial Contractility in a Scalable Hydrogel Culture Platform.

hydrogel platform without being costly or labor-intensive. Our studies found that oxytocin-stimulated calcium responses in myometrial cells are sensitive to nonphysiological matrix conditions. This work highlights the importance of using physiologically relevant engineered microenvironments and represents new directions for understanding myometrial mechanobiology. Our platform can help accelerate the identification of agonists and antagonists to counteract dysfunctional myometrial contractions and can be used more broadly in other tissues that exhibit mechanosensitive pathologies.