Effectiveness of Double‐balloon Enteroscopy‐facilitated Polypectomy in Pediatric Patients With Peutz‐Jeghers Syndrome

ABSTRACT Sizable small‐bowel (SB) polyps in Peutz‐Jeghers syndrome (PJS) pose a high risk for intussusception, often necessitating laparotomy and intraoperative enteroscopy. This series examines the effectiveness of double‐balloon enteroscopy (DBE) facilitated polypectomy for pediatric patients with PJS. Prospective analysis of collected data (6 years) on all patients with PJS referred for DBE‐facilitated SB polypectomy at a pediatric tertiary‐referral center. A total of 16 pediatric patients with PJS were referred for DBE‐facilitated SB polypectomy. Twenty‐two DBEs were performed. Large polyps (≥1 cm) were confirmed in 14 patients. Successful clearance of large SB polyps by DBE or laparoscopically assisted DBE (Lap‐DBE) was achieved in all patients. One patient experienced post‐Lap‐DBE pelvic abscess. All other patients remained asymptomatic and intervention free throughout follow‐up (median 26 months). This series demonstrates that DBE‐facilitated polypectomy is an effective therapeutic option in pediatric patients with PJS. It should be considered at an early age where possible.