下调和上调
癌症研究
小RNA
生物
细胞
细胞生长
基因
遗传学
生物化学
作者
Lin Sun,Taowei Chen,Tao Li,Jianda Yu
出处
期刊:Physiological Genomics
[American Physiological Society]
日期:2019-11-01
卷期号:51 (11): 607-611
被引量:5
标识
DOI:10.1152/physiolgenomics.00062.2019
摘要
We in this study investigated the role of imatinib-upregulated lncRNA (IUR) in prostate carcinoma (PC). We observed that IUR was downregulated in PC, and its expression levels decreased with the increase of clinical stages. In PC tissues, microRNA (miR)-200 was positively, while ZEB1 was inversely correlated with IUR. In PC cells, IUR and miR-200 overexpression mediated the downregulated ZEB1. IUR overexpression mediated the upregulation of miR-200, while IUR expression was not significantly affected by miR-200 overexpression. Cell invasion and migration analysis showed that IUR and miR-200 overexpression resulted in decreased invasion and migration rates. ZEB1 overexpression played an opposite role and attenuated the effects of IUR and miR-200 overexpression. Therefore, IUR can downregulate ZEB1 by upregulating miR-200 to inhibit PC cell invasion and migration.
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