Magnetically induced magnetosome chain (MAGiC):A biogenic magnetic-particle-imaging tracer with high performance and navigability

Abstract Magnetic particle imaging (MPI) enables real-time, sensitive and quantitative visualization of magnetic tracers’ spatial distribution, augmenting the capability of in vivo imaging technologies. Previous tracer studies in MPI have primarily focused on superparamagnetic nanoparticles; however, their non-ideal sigmoidal magnetization response limits the spatial resolution. Here we demonstrate the utilization of magnetically induced magnetosome chain (MAGiC) as a novel superferromagnetic MPI tracer, exhibiting a 25-fold improvement in resolution and a 91-fold enhancement in signal intensity compared to the commercial tracer VivoTrax+™. The spatial resolution of MPI was pushed to an unprecedented 80 μm under a 4 T/m gradient field. Additionally, MAGiC can be precisely controlled using magnetic fields, enabling it to function as a MPI trackable microrobot. We provided a theoretical model elucidating MAGiC’s unique properties, and validated its imaging and actuation performance through phantom studies and in vivo experiments. As a high-performance MPI tracer and magnetic microrobot with exceptional capabilities, MAGiC holds tremendous potential for diverse applications including cell tracking, targeted drug delivery as well as therapeutic interventions.