Antidepressant effects of sulforaphane (SFN) and its derivatives SLL-III-9 and SLL-III-120 and their potential underlying mechanisms based on the microbiota–gut–brain axis

SFN and its derivatives regulate the gut microbiota and intestinal tight junction proteins in CUMS mice, and inhibit the NF-κB/NLRP3 pathway to control the concentration of inflammatory factors and neurotransmitters to combat neuroinflammation.