Unveiling the Various Analytical Techniques of Polyphenols for Pharmacological Activity and Nanotechnological Delivery in Wound Healing

Polyphenols are a diverse group of molecules known for their broad range of biological activities, making them valuable in therapeutic applications, including wound healing. Chronic wounds, which are often complicated by persistent infections and the rise of antibiotic resistance, present a significant challenge in the treatment. Traditional antibiotics are becoming less effective, necessitating the exploration of new antimicrobial agents. Polyphenols like hesperidin, chlorogenic acid, quercetin, and curcumin are promising candidates due to their natural antibacterial properties, offering an effective alternative to conventional antibiotics for treating chronic wounds. However, polyphenols face challenges such as limited stability, which can reduce their effectiveness at the wound site. Furthermore, to overcome these limitations, polymer-based systems have been developed as carriers to stabilize polyphenols and control their release over time, thereby enhancing their therapeutic efficacy. This article explores the potential of polyphenols as natural antibacterial agents and highlights various nanoparticulate systems as effective carriers for treating chronic wounds.