医学
中止
成人斯蒂尔病
语句(逻辑)
甲氨蝶呤
疾病
类风湿性关节炎
内科学
重症监护医学
儿科
政治学
法学
作者
Roberto Giacomelli,Roberto Caporali,Francesco Ciccia,Serena Colafrancesco,Lorenzo Dagna,Marcello Govoni,Florenzo Iannone,Pietro Leccese,Carlomaurizio Montecucco,Giovanni Pappagallo,Giovanni Pistone,Roberta Priori,Piero Ruscitti,Paolo Sfriso,Luca Cantarini
标识
DOI:10.1016/j.autrev.2023.103400
摘要
We performed a comprehensive systematic targeted literature review and used the Delphi method to formulate expert consensus statements to guide the treatment of adult-onset Still's disease (AOSD) to achieve an early and long-term remission. Seven candidate statements were generated and reached consensus in the first round of voting by the panel of experts. We postulate: (i) In patients with AOSD with predominant arthritis at onset who achieved no disease control with glucocorticoids (GCs), the use of methotrexate can be considered, whereas the use of cyclosporin A and low-dose GCs should not (Statements 1–3); (ii) In patients with AOSD with poor prognostic factors at diagnosis, an IL-1 inhibitor (IL-1i) in addition to GCs should be taken into consideration as early as possible (Statement 4); (iii) A switch to an IL-6 inhibitor (IL-6i) may be considered in patients with AOSD with prevalent joint involvement, who are unresponsive or intolerant to IL-1i (Statement 5); (iv) Drug tapering or discontinuation may be considered in patients who achieved a sustained clinical and laboratory remission with IL-1i (Statement 6); (v) In patients with AOSD who failed to attain a good clinical response with an IL-1i, switching to an IL-6i may be considered in alternative to a different IL-1i. TNF-inhibitors may be considered as a further choice in patients with a prominent joint involvement (Statement 7). These statements will help clinicians in treatment decision making in patients with AOSD.
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