Fe(III)-Catalyzed Stereoselective Synthesis of α-Alkenyl-γ-lactams via Radical Cyclization of 1,6-Enyne-Type Ugi 4-CR Adducts

A novel and highly stereoselective synthesis of α-alkenyl-γ-lactams via an Fe(III)-catalyzed radical 5-exo-dig cyclization of 1,6-enyne-type Ugi 4-CR adducts is described. This method operates under mild conditions and requires short reaction times, enabling the efficient construction of these valuable scaffolds while demonstrating broad substrate compatibility and good yields.