吲哚
氮杂环丁烷
级联
催化作用
化学
对映选择合成
立体化学
组合化学
有机化学
色谱法
作者
Xianqiang Zhong,Meirong Huang,Huilan Xiong,Yuzhen Liang,Wei Zhou,Qian Cai
标识
DOI:10.1002/anie.202208323
摘要
Abstract Spiro[azetidine‐indolines] are important scaffolds in diverse bioactive compounds. Current efforts to synthesize spiro[azetidine‐indolines] are limited to chiral spiro[azetidine‐2,3′‐indolines]. Asymmetric synthesis of structurally similar chiral spiro[azetidine‐3,3′‐indolines] remains unexplored. In this work, the first copper(I)‐catalyzed asymmetric Kinugasa/aryl C−C coupling cascade reaction is described. This provides a straightforward access to densely functionalized chiral spiro[azetidine‐3,3′‐indoline]‐2,2′‐diones in good yields and with high enantioselectivity.
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