Physically crosslinked agarose–hyaluronic acid hydrogel for injectable treatment of photoaged skin

, it demonstrates non-pyrogenic and non-hemolytic behavior, enhances tissue hydration, and accelerates regeneration in zebrafish and murine photoaging models. Importantly, Aga-0.5% HA restores dermal density, improves collagen deposition, reduces inflammation, and attenuates oxidative stress. This biocompatible, chemically crosslinker-free hydrogel offers a safe and effective injectable platform for treating photoaged skin and regenerating soft tissue.