ZnCe-LDO Nanozyme-Based Multifunctional Hydrogel Promotes Bone Regeneration by Inflammatory Macrophage Reprogramming and Piezo1 Activation

findings indicated that the GelMA-ZC-Yoda1 hydrogel application improved the inflammatory microenvironment and effectively enhanced osteo/angiogenesis in a rat calvaria defect model. This study supports the advancement of injectable hydrogels with multifunction, including inflammatory macrophage reprogramming and promotion of osteo/angiogenesis.