化学
硼酸
半胱氨酸
组合化学
残留物(化学)
硫醇
点击化学
天然化学连接
纳米技术
生物化学
酶
材料科学
作者
Saurav Chatterjee,Anupam Bandyopadhyay
出处
期刊:Organic Letters
[American Chemical Society]
日期:2023-03-29
卷期号:25 (13): 2223-2227
标识
DOI:10.1021/acs.orglett.3c00386
摘要
The current methods for direct late-stage and residue-selective installation of a versatile boronic acid (BA) repertoire on peptides are inadequate for a wide range of applications. Here, we show the suitability and efficiency of thiol-ene radical click chemistry to install functionally versatile BA derivatives on numerous bioactive, native peptides. Our work highlights that the methodology is operationally simple and adaptable for applications with BA-modified peptides, such as cyclization, conjugation, and functional group alteration.
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