适体
生物标志物
肌红蛋白
纳米技术
心肌梗塞
化学
医学
心脏病学
材料科学
生物
分子生物学
生物化学
有机化学
作者
Siamak Kazemi Asl,Milad Rahimzadegan
标识
DOI:10.1016/j.jpba.2022.114624
摘要
Acute myocardial infarction (AMI) is one of the main health problems, leading to a major rate of mortality and morbidity. Given that myoglobin (Mb) is the earliest rising biomarker after AMI, recent studies have shown that Mb may be considered as a suitable biomarker for the detection of cardiac damage. Recently, aptamer-based biosensors (aptasensors) have attracted special attention for being accessible and their capability for sensitive detection of Mb. Moreover, the nano-aptasensors have provided new advances toward accurate detection of Mb. In this review, we provide an outline of the various types of optical and electrochemical-based aptasensors that have been developed for determination of Mb-related AMI. We also summarized recent developments in the applications of nano-aptasensors for recognition of Mb as an AMI biomarker. Future perspectives and challenges of aptamer-based Mb detection are discussed in brief as well.
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