Cationic polysaccharides: emerging drug delivery vehicle across the physiological mucus barrier

Future Medicinal ChemistryVol. 14, No. 8 CommentaryCationic polysaccharides: emerging drug delivery vehicle across the physiological mucus barrierParteek Prasher, Rabab Fatima & Mousmee SharmaParteek Prasher *Author for correspondence: E-mail Address: parteekchemistry@gmail.comhttps://orcid.org/0000-0002-9412-9424Department of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun, 248007, IndiaSearch for more papers by this author, Rabab FatimaDepartment of Chemistry, University of Petroleum & Energy Studies, Energy Acres, Dehradun, 248007, IndiaSearch for more papers by this author & Mousmee Sharma https://orcid.org/0000-0002-7728-5054Department of Chemistry, Uttaranchal University, Arcadia Grant, Dehradun, 248007, IndiaSearch for more papers by this authorPublished Online:15 Feb 2022https://doi.org/10.4155/fmc-2021-0296AboutSectionsView ArticleView Full TextPDF/EPUB ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareShare onFacebookTwitterLinkedInReddit View articleKeywords: biocompatiblebiodegradablecationic cellulosecationic starchchemical modificationchitosandiaminated starchdrug deliverymucoadhesivemucus penetrationReferences1. Bansil R, Turner BS. The biology of mucus: composition, synthesis and organization. Adv. Drug Deliv. Rev. 124, 3–15 (2018).Crossref, Medline, CAS, Google Scholar2. Leal J, Smyth HDC, Ghosh D. Physicochemical properties of mucus and their impact on transmucosal drug delivery. Int. J. Pharm. 532, 555–572 (2017).Crossref, Medline, CAS, Google Scholar3. Prasher P, Sharma M, Mehta M et al. Current-status and applications of polysaccharides in drug delivery systems. Colloid Interface Sci. Commun. 42, 100418 (2021).Crossref, CAS, Google Scholar4. Prasher P, Fatima R, Sharma M. Therapeutic delivery with V-amylose. Drug Dev. Res. 82, 727–729 (2021).Crossref, Medline, CAS, Google Scholar5. Fatima R, Sharma M, Prasher P. Targeted delivery of flufenamic acid by V-amylose. Ther. Deliv. 12, 575–582 (2021).Link, CAS, Google Scholar6. Prasher P, Fatima R, Sharma M. Resistant starch: ideal candidate for the enteric coating of NSAIDs. Future Med. Chem. 13, 1411–1414 (2021).Link, CAS, Google Scholar7. Mehta M, Prasher P, Sharma M et al. Advanced drug delivery systems can assist in targeting coronavirus disease (COVID-19): a hypothesis. Med. Hypotheses 144, 110254 (2020).Crossref, Medline, CAS, Google Scholar8. Ways TMM, Lau WM, Khutoryanskiy VV. Chitosan and its derivatives for application in mucoadhesive drug delivery systems. Polymers (MDPI) 10, 267 (2018).Crossref, Google Scholar9. Fabiano A, Beconcini D, Migone C, Piras AM, Zambito Y. Quaternary ammonium chitosans: the importance of the positive fixed change of the drug delivery systems. Int. J. Mol. Sci. 21, 6617 (2020).Crossref, CAS, Google Scholar10. Nouri A, Jelkmann M, Khoee S, Schnurch AB. Diaminated starch: a competitor of chitosan with highly mucoadhesive properties due to increased local cationic charge density. Biomacromolecules 21, 999–1008 (2020).Crossref, Medline, CAS, Google Scholar11. Jelkmann M, Leichner C, Menzel C, Kreb V, Schnurch AB. Cationic starch derivatives as mucoadhesive and soluble excipients in drug delivery. Int. J. Pharm. 570, 118664 (2019).Crossref, Medline, CAS, Google Scholar12. Jelkmann M, Menzel C, Baus RA et al. Chitosan: the one and only? aminated cellulose as an innovative option for primary amino groups containing polymers. Biomacromolecules 19, 4059–4067 (2018).Crossref, Medline, CAS, Google Scholar13. Songsurang K, Siraleartmukul K, Muangsin N. Mucoadhesive drug carrier based on functional-modified cellulose as poorly water-soluble drug delivery system. J. Microencapsulation 32, 450–459 (2015).Crossref, Medline, CAS, Google ScholarFiguresReferencesRelatedDetailsCited ByFuture Prospects of Natural Polymer-Based Drug Delivery Systems in Combating Lung Diseases9 February 2023 Vol. 14, No. 8 Follow us on social media for the latest updates Metrics Downloaded 51 times History Received 11 October 2021 Accepted 26 January 2022 Published online 15 February 2022 Published in print April 2022 Information© 2022 Newlands PressKeywordsbiocompatiblebiodegradablecationic cellulosecationic starchchemical modificationchitosandiaminated starchdrug deliverymucoadhesivemucus penetrationFinancial & competing interests disclosureThe authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending or royalties.No writing assistance was utilized in the production of this manuscript.PDF download