贾纳斯激酶
类风湿性关节炎
免疫系统
STAT蛋白
车站3
激活剂(遗传学)
酪氨酸激酶
医学
信号转导
2019年冠状病毒病(COVID-19)
疾病
计算生物学
免疫学
生物
受体
传染病(医学专业)
细胞因子
内科学
细胞生物学
作者
Haiyan Zhou,Changchao Zou,Bing Wang,Chao Li,Muzhi Lin,Lili Mo,Bei Zhang,Niwen Huang,Bo Wei,Xiufang Yang,Wupeng Liu,Guobao Xiong,Zheng Shen,Wei Zhou,Xingde Liu,Wei Li,Mingzhu Gao
出处
期刊:Annals of Translational Medicine
[AME Publishing Company]
日期:2021-01-01
卷期号:10 (11): 635-635
被引量:1
摘要
Patients with rheumatoid arthritis (RA) may be more susceptible to infection by coronavirus disease-19 (COVID-19) due to immune system dysfunction. However, there are still insufficient treatment strategies for patients with RA and COVID-19. Since Jingulian is a traditional Chinese medicine (TCM) with anti-viral and immune regulatory functions, our study aims to explore the detailed mechanisms of Jingulian in treating patients with RA and COVID-19.All the components of Jingulian were retrieved from pharmacology databases. Then, a series of network pharmacology-based analyses and molecular docking were used to understand the molecular functions, core targets, related pathways, and potential therapeutic targets of Jingulian in patients with RA/COVID-19.A total of 93 genes were identified according to the disease-compound-target network. We investigated that the main targets, signaling pathways, and biological functions of Jingulian in RA and COVID-19. Our results indicated that Jingulian may treat patients with RA/COVID-19 through immune processes and viral processes. Moreover, the results of molecular docking revealed that tormentic acid was one of the top compounds of Jingulian, which had high affinity with Janus kinase 1 (JAK1), signal transducer and activator of transcription 3 (STAT3), and epidermal growth factor receptor (EGFR) in patients with RA/COVID-19. Furthermore, 5 core targets of Jingulian were also identified, including JAK1, Janus kinase 2 (JAK2), STAT3, lymphocyte specific protein tyrosine kinase (LCK), and EGFR.Tormentic acid in Jingulian may regulate JAK1, STAT3, and EGFR, and might play a critical role in RA/COVID-19.
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