Objective To investigate the effect of psychological nursing intervention on postoperative glioma cancer related fatigue and quality of life. Methods Dividing 72 patients with glioma randomly into observation group and control group, 36 cases in each group, patients in control group received routine nursing, patients in observation group received psychological intervention on the basis of routine nursing, assess cancer related fatigue and quality of life situations. Results The level of cancer-related fatigue score(34.98±1.54) of observation group was significantly lower than that in the control group. Quality of life score(10.64±1.61) was significantly higher than control group(P0.01). Conclusion The implementation of psychological nursing intervention in glioma patients helps reduce cancer related fatigue and improve quality of life.