Transfection of the Na + /I - symporter gene into tumors for radio-iodide therapy

Na +/I - symporter is a membrane glycoprotein that catalyzes the active accumulation of I -. The abnormality of NIS gene will lead to thyroid disease. We had succeeded in transfecting the Na +/I - symporter into tumors for radioiodide concentration. However, the effective half life is too short to acquire therapeutic dose. So we should research into prolonging the effective half life and increased effective transfection.