The research progress of ornithine decarboxylase and its gene expression in human glioma

Ornithine decarboxylase (ODC) is the first metabolic key enzyme of polyamine metabolism, and the activity of ODC represent biochemical markers of malignancy in glioma. The induction of ODC-gene is closely associated with tumor cell proliferation and invasion, so the ODC-gene has characteristics of oncogenes. Difluoromethylornithine (DFMO), a specific inhibitor of ornithine decarboxylase and the antizyme (AZ)which targets ODC might have potential therapeutical effect for human glioma.