Clinical Study on the Treatment of Continuous Blood Purification Combined with Ulinastatin for Patients with ARDS

Objective: To investigate the effect of continuous blood purification combined Ulinastatin on inflammation of patients with ARDS,as well as the clinical outcomes.Methods: 40 patients suffered from ARDS in our department from May 2011 to December 2012 randomly divided into control group(n=20),and observation group(n=20).The control group received classical treatment and continuous blood purification,and the observation group was added with Ulinastatin.The therapeutic efficacy was observed,the blood gas analysis was evaluated before and after treatment and the oxygenation index was obtained;ELISA was used to quantify the serum concentration of IL-6 and TNF-α.The APACHEⅡscore,duration of mechanical ventilation and ICU stay were observed.Results: ① Compared with control,the oxygenation index increased in observation group(P0.05).② Compared with control,the serum concentration of IL-6 and TNF-α decreased obviously(P0.05).③ After treatment,the APACHE II score of observation group was significantly lower than control group(P0.05).④ Compared with control,the duration of mechanical ventilation and length of ICU stay significantly decreased in observation group(P0.05).Conclusion: Combination of continuous blood purification and Ulinastatin for the treatment of ARDS can increase oxygenation index,inhibit inflammatory response,and improve prognosis.