Changes of Neuron-specific Enolase and Myelin Basic Protein in the Serum and Cerebrospinal Fluid in Patients with Epilepsy after Single Episodes

Objective To detect the possibility of brain damage in the epileptic patients after single episodes. Methods The levels of neuron-specific enolase(NSE)in serum and cerebrospinal fluid(CSF)in 40patients with single episodes within 24hours after seizures from June 2007to November 2009were determined respectively by electrochemiluminescence.Another 40healthy individuals were enrolled as the control.The levels of myelin basic protein(MBP)were determined by enzyme-linked immunosorbent assay.Results The levels of NSE in the serum and CSF in epileptic group within 24hours after seizures were significantly higher than those in the control group(P 0.01),and the levels of MBP in the serum in the two group didn′t differ much(P0.05).The levels of MBP in CSF in epileptic group were significantly higher than those in the control group(P0.05).Conclusions After single episodes,the levels of NSE in serum and CSF and the levels of NSE in CSF increase,which suggests that single episodes may lead to neuronal damage.