Astragalus membranaceus Extract as a Botanical Ingredient for Pigmentary and Anti-Aging Skincare: A Systematic Review

BACKGROUND: Skin aging results from intrinsic and extrinsic factors, including oxidative stress, ultraviolet (UV) radiation, and declining cellular functions. These factors lead to visible changes like rhytids, pigmentation, and loss of elasticity. Meanwhile, interest in plant-based skincare ingredients for skin aging has been increasing. OBJECTIVE: This systematic review investigates the anti-aging potential of Astragalus membranaceus, a botanical plant. The authors focused on its active components and their roles in dermal protection, antioxidant, anti-inflammatory, anti-aging properties, and telomere elongation. METHODS: A comprehensive PubMed search from 2015 to 2025 per PRISMA guidelines identified clinical and experimental studies assessing the anti-aging effects of Astragalus membranaceus. RESULTS: Bioactive compounds, including astragaloside IV, cycloastragenol, flavonoids, and polysaccharides, showed photoprotective effects, including reactive oxygen species (ROS) reduction, inflammatory signaling inhibition, mitochondrial preservation, and promotion of collagen synthesis. Elongation of telomeres under oxidative stress was also demonstrated with Astragaloside IV. Clinical trials showed improvements in skin hydration, tone, and wrinkle reduction. CONCLUSION: Astragalus membranaceus offers promise as a botanical anti-aging agent. Its effects on collagen, oxidative defense, and telomere preservation support its potential use in cosmeceuticals. However, further randomized trials are needed to confirm long-term efficacy and safety. .