肝星状细胞
微泡
癌症研究
癌变
化学
MAPK/ERK通路
细胞生物学
信号转导
分泌物
转化(遗传学)
细胞信号
肝细胞癌
小RNA
恶性转化
外体
下调和上调
肝细胞癌
肿瘤微环境
生物
细胞外小泡
细胞生长
作者
Xiaona Lu,Jia Shi,Wenlan Zheng,Shihan Yu,Xue Zhang,Hai Feng,Zhi Shang,Zhuo Yu
标识
DOI:10.1016/j.jare.2026.01.038
摘要
Our results indicate that activated HSCs secrete exosomes enriched with miR-23a-3p, which directly target to inhibit DUSP5, and subsequently activate ERK signaling in hepatocytes, leading to the initiation of cellular malignant transformation and tumorigenesis.
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