双环分子
化学
吡啶
羧酸盐
组合化学
戒指(化学)
比例(比率)
立体化学
烟碱激动剂
过程(计算)
药物化学
有机化学
受体
计算机科学
物理
操作系统
量子力学
生物化学
作者
Lokesh Babu Jarugu,China Anki Reddy,Nanjundaswamy Kanikahalli Chikkananjunda,Suresh Krishnamoorthy,Pon Sarvanakumar,Ulaganathan Sankar,Pirama Nayagam Arunachalam,Ivar M. McDonald,R. E. Olson,Richard Rampulla,Arvind Mathur,Anuradha Gupta
标识
DOI:10.1021/acs.oprd.8b00208
摘要
An optimized large-scale synthesis of (2S,3aR,7aS)-tert-butyl hexahydro-2,5-methanopyrrolo[3,2-c]pyridine-1(4H)-carboxylate (1A), an important intermediate for nicotinic acetylcholine receptor agonists, is described. The key feature of the synthesis involves three transformations in a one-pot process, including debenzylation and ring hydrogenation of two fused bicyclic rings. Multihundred gram quantities of 1A were prepared.
科研通智能强力驱动
Strongly Powered by AbleSci AI