Abstract Two new homoisoflavanones were isolated from the rhizomes of Polygonatum odoratum (Mill.) Druce and their structures were elucidated as (3 R )-5,7-dihydroxy-8-methoxy-3-(4-methoxybenzyl)-6-methylchrom-an-4-one ( 1 ) and (3 R )-5,7,8-trihydroxy-3-(4-hydroxybenzyl)-6-methylchroman-4-one ( 2 ), on the basis of sp-ectral analysis.