PLGA公司
药品
药物输送
乙醇酸
控制释放
剂型
化学
药理学
生化工程
纳米技术
乳酸
计算机科学
材料科学
有机化学
医学
生物化学
色谱法
体外
生物
工程类
细菌
遗传学
作者
Susanne Fredenberg,Marie Wahlgren,Mats Reslow,Anders Axelsson
标识
DOI:10.1016/j.ijpharm.2011.05.049
摘要
Poly(D,L-lactic-co-glycolic acid) (PLGA) is the most frequently used biodegradable polymer in the controlled release of encapsulated drugs. Understanding the release mechanisms, as well as which factors that affect drug release, is important in order to be able to modify drug release. Drug release from PLGA-based drug delivery systems is however complex. This review focuses on release mechanisms, and provides a survey and analysis of the processes determining the release rate, which may be helpful in elucidating this complex picture. The term release mechanism and the various techniques that have been used to study release mechanisms are discussed. The physico-chemical processes that influence the rate of drug release and the various mechanisms of drug release that have been reported in the literature are analyzed in this review, and practical examples are given. The complexity of drug release from PLGA-based drug delivery systems can make the generalization of results and predictions of drug release difficult. However, this complexity also provides many possible ways of solving problems and modifying drug release. Basic, generally applicable and mechanistic research provides pieces of the puzzle, which is useful in the development of controlled-release pharmaceuticals.
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