薗头偶联反应
荧光
嘌呤
化学
脱氧腺苷
聚集诱导发射
生物物理学
组合化学
光化学
纳米技术
生物化学
腺苷
钯
材料科学
生物
催化作用
物理
酶
量子力学
作者
Xin He,Shuang Kuang,Qian Gao,YuXin Xie,Xin Ming
标识
DOI:10.1080/15257770.2021.2004418
摘要
Modified bright fluorescent nucleosides that respond to the microenvironment have great potential as probes. A series of novel 8-(phenylethynyl)phenylated 2-amino-2'-deoxyadenosine and 2'-deoxyisoguanosine derivatives have been synthesized by Sonogashira-type coupling reaction and Suzuki reaction. The maximum emission of the new compounds is in the visible region, with strong solvatochromicity and pH-dependent fluorescent properties. Furthermore, some of them exhibit bright fluorescence emissions in various solvents (ε × Φ = 4000-39,000 cm-1 M-1). These consequences indicate that purine analogues could respond to the microenvironment and serve as promising fluorescent probes.Supplemental data for this article is available online at https://doi.org/10.1080/15257770.2021.2004418 .
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