RAR相关孤儿受体γ
免疫学
白细胞介素17
银屑病
炎症
先天性淋巴细胞
胸腺基质淋巴细胞生成素
相扑蛋白
细胞因子
免疫系统
生物
白细胞介素23
泛素
医学
FOXP3型
遗传学
获得性免疫系统
基因
作者
Ritesh Kumar,Arianne L. Theiss,K. Venuprasad
标识
DOI:10.1016/j.it.2021.09.005
摘要
RORγt, the master transcription factor for cytokine interleukin (IL)-17, is expressed explicitly in Th17 cells, γδT cells, and type 3 innate lymphoid cells in mice and humans. Since dysregulated IL-17 expression is strongly linked to several human inflammatory diseases, the RORγt-IL-17 axis has been the focus of intense research. Recently, several studies have shown that RORγt is modified by multiple post-translational mechanisms, including ubiquitination, acetylation, SUMOylation, and phosphorylation. This review discusses how post-translational modifications modulate RORγt function and its turnover to regulate IL-17-driven inflammation. Broad knowledge of these pathways is crucial for a clear understanding of the pathogenic role of RORγt+IL-17+ cells and for the development of putative therapeutic strategies to target IL-17-driven diseases such as multiple sclerosis, psoriasis, rheumatoid arthritis, systemic lupus erythematosus, and inflammatory bowel disease.
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