半日花
二萜
姜科
绝对构型
根茎
立体化学
化学
酒
高良姜
绝对(哲学)
非对映体
传统医学
有机化学
医学
哲学
认识论
作者
Phan Minh Giang,Phan Tống Sơn,Hideaki Otsuka
摘要
The labdane-type diterpene 15,16-epoxy-8(17),13(16),14-labdatrien-12ξ-ol (1) was isolated together with 2'-hydroxy-4',6'-dimethoxychalcone and 2,3-dihydro-4',7-di-O-methylkaempferol from the rhizomes of the endemic Vietnamese medicinal plant Alpinia tonkinensis Gagnep. (Zingiberaceae). Although both diastereomers of the furanolabdane alcohol 1 provided by the chiral center at the 12-position have already been reported as semisynthetic intermediates, the absolute configuration at the 12-position, which affects the chemical shifts of the 17-exomethylene protons, remains to be clarified. In this study, the natural furanolabdane 1, which possessed the same 1Hand 13C-NMR spectroscopic data as those of one of the semisynthetic diastereoisomeric pair, was determined to be in the (12S)-form from spectroscopic data and by applying the modified Mosher's method. Author
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