血管生成
小RNA
生物
竞争性内源性RNA
功能(生物学)
机制(生物学)
新生血管
生物信息学
细胞生物学
核糖核酸
长非编码RNA
癌症研究
神经科学
计算生物学
遗传学
基因
认识论
哲学
作者
Zhuo Zhao,Weiyi Sun,Ziyuan Guo,Jichang Zhang,Hongyu Yu,Bin Liu
出处
期刊:Life Sciences
[Elsevier]
日期:2020-08-01
卷期号:254: 116900-116900
被引量:185
标识
DOI:10.1016/j.lfs.2019.116900
摘要
Angiogenesis is a complex physiological process. However, over the past couple of decades, abnormally accelerated or pathological angiogenesis has garnered greater attention from researchers the world over. Studies have shown that this abnormal and uncontrolled angiogenesis not only promotes inflammatory responses but also plays a role in various malignant and cardiovascular diseases. These include solid tumors, atherosclerosis, blinding retinopathy, and other diseases. Furthermore, there is mounting evidence that noncoding RNAs, especially lncRNAs and microRNAs, play important roles in the regulation of angiogenesis. In recent years, numerous studies have found that lncRNA may serve as an endogenous sponge to regulate the expression and function of miRNA, which in turn bind to lncRNA, regulating their stability. Therefore, this review focuses on the mechanisms of lncRNA/microRNA interactions in angiogenesis. A better understanding of such lncRNA/microRNA interactions may provide helpful insights and shed new light on areas of research for identifying diagnostic markers and therapeutic approaches for treating angiogenesis-related diseases.
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