医学
泌尿系统
脑病
新生儿脑病
儿科
内科学
尿
肝性脑病
作者
José David Piñeiro-Ramos,Mari Merce Cascant,Antonio Núñez-Ramiro,Ángeles López-Gonzálvez,Álvaro Solaz-García,Abel Albiach-Delgado,Juan Martínez-Rodilla,Roberto Llorens-Salvador,Daniel Sanjuan-Herráez,Guillermo Quintás,Coral Barbas,Julia Kuligowski,Máximo Vento
标识
DOI:10.1038/s41390-021-01553-z
摘要
Infants with moderate and severe neonatal encephalopathy (NE) frequently suffer from long-term adverse outcomes. We hypothesize that the urinary metabolome of newborns with NE reflects the evolution of injury patterns observed with magnetic resonance imaging (MRI). Eligible patients were newborn infants with perinatal asphyxia evolving to NE and qualifying for therapeutic hypothermia (TH) included in the HYPOTOP trial. MRI was employed for characterizing brain injury. Urine samples of 55 infants were collected before, during, and after TH. Metabolic profiles of samples were recorded employing three complementary mass spectrometry-based assays, and the alteration of detected metabolic features between groups was assessed. The longitudinal assessment revealed significant perturbations of the urinary metabolome. After 24 h of TH, a stable disease pattern evolved characterized by the alterations of 4–8% of metabolic features related to lipid metabolism, metabolism of cofactors and vitamins, glycan biosynthesis and metabolism, amino acid metabolism, and nucleotide metabolism. Characteristic metabolomic fingerprints were observed for different MRI injury patterns. This study shows the potential of urinary metabolic profiles for the noninvasive monitoring of brain injury of infants with NE during TH.
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