Plasmonic Nanozyme of Graphdiyne Nanowalls Wrapped Hollow Copper Sulfide Nanocubes for Rapid Bacteria‐Killing

Abstract Plasmon stimulation represents an appealing way to modulate enzyme mimic functions, but utilization efficiency of plasmon excitation remains relatively low. To overcome this drawback, a heterojunction composite based on graphdiyne nanowalls wrapped hollow copper sulfide nanocubes (CuS@GDY) with strong localized surface plasmon resonance (LSPR) response in the near‐infrared (NIR) region is developed. This nanozyme can concurrently harvest LSPR induced hot carriers and produce photothermal effects, resulting in dramatically increased peroxidase‐like activity when exposed to 808 nm light. Both experimental results and theoretical calculations show that the remarkable catalytic performance of CuS@GDY is due to the unique hierarchical structure, narrow bandgap of GDY nanowalls, LSPR effect of CuS nanocages, fast interfacial electron transfer dynamics, and carbon vacancies on CuS@GDY. This plasmonic nanozyme exhibits rapid, efficient, broad‐spectrum antibacterial activity ( > 99.999%) against diverse pathogens (methicillin‐resistant Staphylococcus aureus , Staphylococcus aureus , and Escherichia coli ). This study not only sheds light on the mechanism of the nanozyme‐/photocatalysis coupling process, but also opens up a new avenue for engineering plasmonic NIR light driven nanozymes for rapid synergistic photothermal and photo‐enhanced nanozyme therapy.