Basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) are the most common skin malignancies. BCC and SCC are affecting the corresponding cells in the epidermis where tumorogenesis starts. The onset of these diseases is caused by sun exposure and ultraviolet radiation (UVR). However, it seems that there are more vulnerable groups within the population. Several other leading factors have been described in the literature. Elderly, male and fair-skinned individuals may have significantly increased skin cancer risk. Understanding the characteristics of these cancers epidemiology may allow their early detection and ensure better medical and surgical management. Keywords: Skin cancer risk; Ultraviolet radiation; Sun exposure; Sun protection; Review.