[Association between depression tendency and cognitive trajectory in the elderly in rural area in China].

Objective: To explore cognitive trajectory and its association with depression tendency in the elderly in rural area in China. Methods: Based on the data of the rural elderly aged ≥65 years in the Chinese Longitudinal Healthy Longevity Survey (CLHLS) from 2011 to 2018, unconditional and conditional latent variable growth curve models were constructed to analyze the mini-mental state examination (MMSE) score trajectory and its association with depression tendency in the elderly. Results: A total of 1 788 elderly persons were included, and 19.1% of them had a depression tendency. The average MMSE score of those with and without a depression tendency at baseline survey were 26.62±3.54 and 27.59±3.17 respectively. The rate of MMSE score decline was 0.52 points (P<0.05). Before and after controlling covariates, the initial score was 0.84 points lower (P<0.05) and 0.81 points lower (P<0.05) in those with depressive tendency than in those without depressive tendency respectively, furthermore, the decline rate of MMSE score was 0.33 points lower (P<0.05) and 0.40 points lower (P<0.05) in those with depressive tendency than in those without respectively. Conclusions: The depression tendency in the elderly in rural area in China was associated with the cognitive function change trajectory, with those with depression tendency had lower-level trajectory. Attention should be paid to the mental health of the elderly in rural area to prevent dementia and slow its development.目的： 探索我国农村老年人抑郁倾向与认知功能变化轨迹的关系。 方法： 基于中国老年健康影响因素跟踪调查（CLHLS）中2011-2018年农村≥65岁老年人的数据，分别构建无条件和条件潜变量增长曲线模型，分析我国农村老年人简易精神状态评价量表（MMSE）得分变化轨迹及与抑郁倾向的关系。 结果： 最终纳入了1 788名2011/2012年开始调查的农村老年人，其中有抑郁倾向者占19.1%；有、无抑郁倾向者基线MMSE得分别为26.62±3.54和27.59±3.17。无条件和条件潜变量增长曲线模型结果显示：MMSE得分下降率为0.52分（P<0.05）；纳入协变量前后，有抑郁倾向者MMSE初始得分比无抑郁倾向者分别低0.84分（P<0.05）和0.81分（P<0.05），有抑郁倾向者MMSE得分下降速度比无抑郁倾向者分别慢0.33分（P<0.05）和0.40分（P<0.05）。 结论： 我国农村老年人抑郁倾向与认知功能变化轨迹有关，有抑郁倾向者处于更低水平轨迹，提示应积极关注我国农村老年人的心理健康并及时干预，以延缓或防止老年痴呆的发生发展。.