肾功能
肾毒性
医学
透皮
重症监护医学
泌尿科
肾
内科学
药理学
作者
Thomas P. Mullins,Daniel Schock-Kusch,Linda A. Gallo
出处
期刊:Methods in molecular biology
日期:2023-01-01
卷期号:: 309-315
标识
DOI:10.1007/978-1-0716-3179-9_19
摘要
The measurement of glomerular filtration rate (GFR) is essential to understanding renal physiology, including the monitoring of disease progression and treatment effectiveness. Transdermal measurement of glomerular filtration rate (tGFR) using a miniaturized fluorescence monitor in combination with a fluorescent exogenous GFR tracer has become a common technique to measure GFR in the preclinical setting, especially in rodent models. It allows for close to real-time measurement of GFR in conscious unrestrained animals and overcomes several limitations of other GFR measures. Its widespread use is reflected by published research articles and conference abstracts from different research fields, including in the assessment of new and existing kidney therapeutics, evaluation of nephrotoxicity, screening of novel chemical or medical agents, and fundamental understanding of kidney function.
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