DRP1-Mediated Mitophagy: Safeguarding Obese Hearts From Cardiomyopathy

Obesity and metabolic syndrome are commonly associated with an increased risk of cardiovascular disease.Obesity-induced cardiomyopathy is characterized by morphological, functional, and metabolic abnormalities in hearts of obese individuals, independent of other cardiovascular risk factors.Mitochondrial dysfunction is frequently associated with obesityinduced cardiomyopathy and is a major contributor to its pathogenesis 1 .