炔基化
对映选择合成
芳基
催化作用
恶唑啉
基质(水族馆)
配体(生物化学)
化学
药物化学
组合化学
有机化学
地质学
受体
烷基
生物化学
海洋学
作者
Baomin Fan,Siyi Luo,Meifen Wang,Baomin Fan,Bo Yao
标识
DOI:10.1021/acs.joc.3c02807
摘要
An efficient method for the synthesis of five-membered chiral propargylic amines from 2-aryl-3H-indol-3-one and alkynylsilanes has been developed. The reaction proceeded under the catalytic system of PtCl4, oxazoline-based ligand L11, Zn(CF3COO)2, and AcOH in DCE at 95 °C via in situ desilylation of TMS-alkynes. This methodology also highlights a new protocol for the in situ desilylation of alkynylsilanes. The reaction showed a broad substrate scope with good yields and enantioselectivity.
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