Clonal hematopoiesis of indeterminate potential and risk of hepatocellular carcinoma: New kids on the block

1Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center, Los Angeles, CA, USA 2California NanoSystems Institute, Crump Institute for Molecular Imaging, Department of Molecular and Medical Pharmacology, University of California, Los Angeles, Los Angeles, California, USA 3Jonsson Comprehensive Cancer Center, University of California, Los Angeles, Los Angeles, California, USA 4Comprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, CA, USA 5Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, CA, USA Abbreviations: ALD, alcohol-associated liver diseases; CHIP, clonal hematopoiesis of indeterminate potential; CI, confidence interval; HCC hepatocellular carcinoma; MASH, metabolic dysfunction-associated steatohepatitis; MASLD, metabolic dysfunction-associated steatotic liver diseases; OR, odds ratio; PRS-5, polygenic risk score-5; VAF, variant allele frequency. Correspondence Ju Dong Yang, Medical Director, Liver Cancer Program Karsh Division of Gastroenterology and Hepatology, Cedars-Sinai Medical Center Health Sciences Associate Clinical Professor, University of California, Los Angeles 8700 Beverly Blvd, Los Angeles, CA – 90048. Email: [email protected]