神经酰胺
神经酰胺合酶
秀丽隐杆线虫
突变体
生物
鞘脂
ATP合酶
生物发生
细胞生物学
信号转导
生物化学
脂质信号
基因
酶
细胞凋亡
作者
Vincent Menuz,Kate Howell,Sébastien Gentina,Sharon Epstein,Isabelle Riezman,Monique Fornallaz-Mulhauser,Michael O. Hengartner,Marie Gomez,Howard Riezman,Jean‐Claude Martinou
出处
期刊:Science
[American Association for the Advancement of Science (AAAS)]
日期:2009-04-17
卷期号:324 (5925): 381-384
被引量:156
标识
DOI:10.1126/science.1168532
摘要
Oxygen deprivation is rapidly deleterious for most organisms. However, Caenorhabditis elegans has developed the ability to survive anoxia for at least 48 hours. Mutations in the DAF-2/DAF-16 insulin-like signaling pathway promote such survival. We describe a pathway involving the HYL-2 ceramide synthase that acts independently of DAF-2. Loss of the ceramide synthase gene hyl-2 results in increased sensitivity of C. elegans to anoxia. C. elegans has two ceramide synthases, hyl-1 and hyl-2, that participate in ceramide biogenesis and affect its ability to survive anoxic conditions. In contrast to hyl-2(lf) mutants, hyl-1(lf) mutants are more resistant to anoxia than normal animals. HYL-1 and HYL-2 have complementary specificities for fatty acyl chains. These data indicate that specific ceramides produced by HYL-2 confer resistance to anoxia.
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