透明质酸
自愈水凝胶
离解(化学)
超声波
按需
化学
体内
生物医学工程
生物物理学
纳米技术
化学工程
材料科学
高分子化学
有机化学
计算机科学
解剖
生物技术
工程类
物理
生物
医学
多媒体
声学
作者
Jae Yoon An,Wooram Um,Dong Gil You,Yeari Song,Jeongjin Lee,Nguyễn Văn Qúy,Hyeyeon Joo,Jueun Jeon,Jae Hyung Park
标识
DOI:10.1016/j.ijbiomac.2021.10.071
摘要
The temporal and quantitative control of the cargo release is a challenging issue in the application of hydrogels for cancer therapy. Here, we report hyaluronic acid hydrogel-based depot that provides ultrasound-triggered thermal elevation and on-demand cargo release. The hyaluronic acid hydrogel was developed by employing the gold cluster as a sonothermal crosslinker which was grown on the cargo to prevent its undesired leakage until ultrasound-induced dissociation. The results demonstrated that, in the presence of ultrasound at 30 W, the hyaluronic acid hydrogel significantly increased the temperature to 53.7 °C, leading to dissociation of gold clusters and subsequent cargo release. In addition, the prepared hydrogel exhibited appropriate mechanical properties and superior biostability as an injectable hydrogel for in vivo applications.
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