The Cytotoxic Effect of Gold Polyacrylate (Aurumacryl) on Human Skin Fibroblasts

The cytotoxic effect of the potential antitumor drug aurumacryl (gold polyacrylate) on human skin fibroblast cell line hFB-hTERT6 has been studied in vitro. It has been found that aurumacryl exhibits substantial cytotoxicity to human skin fibroblasts. The maximum cytotoxic effect (75% cell death) is observed at an aurumacryl concentration of 0.125 mg/mL. The inhibitory concentration of aurumacryl that causes 50% human skin fibroblast death ( IC 50 ) is 0.09 mg/mL.