脂肪性肝炎
肝硬化
脂肪肝
医学
细胞外小泡
胞外囊泡
肝病
微泡
肝移植
肝再生
酒精性肝炎
酒精性肝病
慢性肝病
肝损伤
肝炎
原发性胆汁性肝硬化
病毒性肝炎
细胞生物学
疾病
免疫学
外体
化学
小泡
体内
细胞外
再生(生物学)
微泡
生物
癌症研究
移植
药理学
胃肠病学
病理
内科学
作者
Enis Kostallari,Shantha Valainathan,Louise Biquard,Vijay H. Shah,Pierre‐Emmanuel Rautou
标识
DOI:10.1016/j.addr.2021.05.026
摘要
More than eight hundred million people worldwide have chronic liver disease, with two million deaths per year. Recurring liver injury results in fibrogenesis, progressing towards cirrhosis, for which there doesn't exists any cure except liver transplantation. Better understanding of the mechanisms leading to cirrhosis and its complications is needed to develop effective therapies. Extracellular vesicles (EVs) are released by cells and are important for cell-to-cell communication. EVs have been reported to be involved in homeostasis maintenance, as well as in liver diseases. In this review, we present current knowledge on the role of EVs in non-alcoholic fatty liver disease and non-alcoholic steatohepatitis, alcohol-associated liver disease, chronic viral hepatitis, primary liver cancers, acute liver injury and liver regeneration. Moreover, therapeutic strategies involving EVs as targets or as tools to treat liver diseases are summarized.
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