上睑下垂
背景(考古学)
免疫系统
肿瘤微环境
细胞生物学
程序性细胞死亡
神经科学
生物
免疫学
炎症体
炎症
细胞凋亡
遗传学
古生物学
作者
Tiantian Du,Jie Gao,Peilong Li,Yunshan Wang,Qiuchen Qi,Xiaoyan Liu,Juan Li,Chuanxin Wang,Du Li
摘要
In response to a wide range of stimulations, host cells activate pyroptosis, a kind of inflammatory cell death which is provoked by the cytosolic sensing of danger signals and pathogen infection. In manipulating the cleavage of gasdermins (GSDMs), researchers have found that GSDM proteins serve as the real executors and the deterministic players in fate decisions of pyroptotic cells. Whether inflammatory characteristics induced by pyroptosis could cause damage the host or improve immune activity is largely dependent on the context, timing, and response degree. Here, we systematically review current points involved in regulatory mechanisms and the multidimensional roles of pyroptosis in several metabolic diseases and the tumor microenvironment. Targeting pyroptosis may reveal potential therapeutic avenues.
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