The Encounter of Biomolecules in Metal–Organic Framework Micro/Nano Reactors

In nature, biochemical reactions often take place in confined spaces, as typically exemplified by cells. As numerous cellular reactors can be integrated to maintain the living system, researchers have made constant efforts to construct cell-like structures for achieving similar transformations in vitro. Micro/nano reactors engineered by polymers and colloids are becoming popular and being applied in many fields, especially there has been an increasing trend toward constructing metal-organic framework (MOF) micro/nano reactors with the thriving of MOF nanotechnologies. Because of the uniform pores of MOFs, the transmission of substances can be regulated more accurately. Along with properties of large specific surface area, functional diversity and precise control of the particle size, MOFs are also ideal platforms for building distinct microenvironments for biological substances. Compared with traditional polymersomes and colloidosomes, the unique characteristics of MOFs render them potent micro/nano reactor shell materials, mimicking cells for applications in enzymatic catalysis, sensing, nanotherapy, vaccine, biodegradation, etc. This review highlights recent signs of progress on the design of MOF micro/nano reactors and their applications in biology, discusses the existing problems, and prospects their promising properties for smarter multifunctional applications.