生物
效应器
启动(农业)
细胞毒性T细胞
MHC I级
细胞内寄生虫
CD8型
T细胞
细胞内
抗原呈递
抗原
细胞生物学
主要组织相容性复合体
微生物学
免疫系统
免疫学
遗传学
发芽
植物
体外
作者
John T. Harty,Michael J. Bevan
标识
DOI:10.1016/s0952-7915(99)80016-8
摘要
Recent studies of CD8(+) T cell responses against intracellular bacteria have provided insights into the relevance of the exogenous and endogenous MHC class I presentation pathways during the priming and effector stages. The capacity of these organisms to deliver vaccine antigens, either as bacterial protein or as plasmid DNA expressed by host antigen-presenting cells, has been investigated. Ongoing studies of CD8(+) T cell effector functions suggest the existence of novel pathways of resistance to bacterial infection. These results, together with advances in our understanding of nonclassical MHC class I presentation, reveal the impact of pathogen biology on host immunity to infection.
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