Evaluation of different ranges of LH:FSH ratios in polycystic ovarian syndrome (PCOS) – Clinical based case control study

Abstract Background Polycystic ovary syndrome (PCOS) is a highly prevalent endocrine and metabolic disorder among reproductive aged women, leading to infertility. One of the common clinical manifestations in PCOS is that there is a difference in the range of LH production in different case of PCOS and accordingly variability in LH:FSH ratio was observed. Objective The aim of the present study was to evaluate different ranges of LH:FSH ratios in PCOS. Experimental design In this cross sectional study, a consecutive series of 745 women (aged 28.11 ± 0.2) who were subjected to infertility treatment at specialist infertility clinics in central Travancore region were considered. About 50 healthy females (aged 27.58 ± 0.4) with regular menstrual cycles were regarded as control. The data were collected from hospital records using subject’s written informed consent. Results PCOS patients were observed to have different ranges of LH:FSH ratios from  Conclusion This finding suggested a dependence of insulin, LH and testosterone in initiating the hormonal imbalances in PCOS.